COMMON FIXED POINT THEOREMS IN POLISH SPACE FOR NONSELF MAPPING

We prove some Common Fixed Point theorems for Random Operator in polish spaces, by using some new type of contractive conditions taking non-self mappings. Key Words: - Polish Space, Random Operator, Random   Multivalued Operator, Random Fixed             Point,   Measurable Mapping, Non-self mappin

Survey performance Improvement FP-Tree Based Algorithms Analysis

Construction of a compact FP-tree ensures that subsequent mining can be performed with a rather compact data structure. For large databases, the research on improving the mining performance and precision is necessary; so many focuses of today on association rule mining are about new mining theories, algorithms and improvement to old methods. Association rules mining is a function of data mining research domain and arise many researchers interest to design a high efficient algorithm to mine association rules from transaction database. Generally the entire frequent item sets discovery from the database in the process of association rule mining shares of larger, these algorithms considered as efficient because of their compact structure and also for less generation of candidates item sets compare to Apriori .the price is also spending more. This paper introduces an improved aprior algorithm so called FP-growth algorithm

Role of Growth Factor Signaling in Cancer

Growth factors may be defined as any group of protein that stimulate the growth of specific tissues and play an important role in promoting cellular differentiation and cellular division. Growth factors impart one of the important hallmark of cancer i.e sustaining proliferative signaling. They may act through paracrine, autocrine and endocrine signaling to effect growth and proliferation of cancer cells. They may act through various signaling cascades like MAPK, PI3K/AKT, JAK/STAT etc to activate their downstream mediates affecting various pathlogical and physiological functions. Abrupt signaling patterns of growth factors can induce oncogenic transformations. An enhanced understanding of these pathways can help targeting neoplastic transformation at an early stage. This review summarizes various mechanisms for targeted therapeutics against growth factor in cancer and their future prospective.

FP-Growth Tree Based Algorithms Analysis: CP-Tree and K Map

We propose a novel frequent-pattern tree (FP-tree) structure; our performance study shows that the FP-growth method is efficient and scalable for mining both long and short frequent patterns, and is about an order of magnitude faster than the Apriori algorithm and also faster than some recently reported new frequent-pattern mining methods. FP-tree method is efficient algorithm in association mining to mine frequent patterns in data mining, in spite of long or short frequent data patterns. By using compact best tree structure and partitioning-based and divide-and-conquer data mining searching method, it can be reduces the costs searchsubstantially .it just as the analysis multi-CPU or reduce computer memory to solve problem. But this approach can be apparently decrease the costs for exchanging and combining control information and the algorithm complexity is also greatly decreased, solve this problem efficiently. Even if main adopting multi-CPU technique, raising the requirement is basically hardware, best performanceimprovement is still to be limited. Is there any other way that most one may it can reduce these costs in FP-tree construction, performance best improvement is still limited

Interaction of viral proteins with metal ions: role in maintaining the structure and functions of viruses

Metal ions are integral part of some viral proteins and play an important role in their survival and pathogenesis. Zinc, magnesium and copper are the commonest metal ion that binds with viral proteins. Metal ions participate in maturation of genomic RNA, activation and catalytic mechanisms, reverse transcription, initial integration process and protection of newly synthesized DNA, inhibition of proton translocation (M2 protein), minus- and plus-strand transfer, enhance nucleic acid annealing, activation of transcription, integration of viral DNA into specific sites and act as a chaperone of nucleic acid. Metal ions are also required for nucleocapsid protein-transactivation response (TAR)-RNA interactions. In certain situations more than one metal ion is required e.g. RNA cleavage by RNase H. This review underscores the importance of metal ions in the survival and pathogenesis of a large group of viruses and studies on structural basis for metal binding should prove useful in the early design and development of viral inhibitors

Dengue and dengue haemorrhagic fever: implications of host genetics

Little is known of the role of human leucocyte antigen (HLA) alleles or non-HLA alleles in determining resistance, susceptibility or the severity of acute viral infections. Dengue fever (DF) and dengue haemorrhagic fever (DHF) are suitable models for immunogenetic studies, yet only superficial efforts have been made to study dengue disease to date. DF and DHF can be caused by both primary and secondary infection by any of the four serotypes of the dengue virus. Differences in host susceptibility to infectious disease and disease severity cannot be attributed solely to the virus virulence. Variations in immune response, often associated with polymorphism in the human genome, can now be detected. Data on the influence of human genes in DF and DHF are discussed here in relation to (1) associations between HLA polymorphism and dengue disease susceptibility or resistance, (2) protective alleles influencing progression to severe disease, (3) alleles restricting CD4+ and CD8+ T lymphocytes, and (4) non-HLA genetic factors that may contribute to DHF evolution. Recent discoveries regarding genetic associations in other viral infections may provide clues to understanding the development of end-stage complications in dengue disease. The scanty positive data presented here indicate a need for detailed genetic studies in different ethnic groups in different countries during the acute phase of DF and DHF on a larger number of patients

Various cells of the immune system and intestine differ in their capacity to reduce hexavalent chromium

The cells of the immune system form a strong line of defence against foreign substances. The present study was undertaken to investigate the capacity of different cells of Wistar rats to reduce potentially carcinogenic hexavalent chromium (Cr-VI) into less toxic trivalent chromium in vitro. 5× 106 cells were incubated with 10 or 25 μ g ml-1 of Cr (VI) in the form of K2Cr2O7 at 37° C in the presence of 5% CO2 in air. At various time periods the remaining amount of Cr (VI) was measured and the percentage of Cr (VI) reduced was calculated. Among the single cell suspensions from the splenic cells a peak reduction of 55% was observed with the total spleen cells, 40% with the B-lymphocyte-enriched subpopulation, 10% with T-lymphocytes and 24% with the macrophages. The reduction by splenic and peritoneal macrophages was similar. Total thymocytes reduced 54% of the Cr (VI). Since the most common route of entry of chromium is through drinking water and food, intestinal cells were also investigated. Among the intestinal cells the maximum reduction of 100% (of 10 μ g ml-1) was observed with the upper villus cells and 72% with the middle villus cells while reduction was the least (4%) with the crypt cells. The reduction in the intestinal loop in situ was 100%. The time taken by each cell type for the peak reduction to Cr (VI) was markedly different. The findings thus show that the capacity of different cells in the body differs vastly in their capacity and time taken to reduce hexavalent chromium. The most efficient handling of Cr (VI) by the intestine, due to the presence of a variety of cells and bacteria, protects the body from its adverse effects

Gut microflora & toxic metals: chromium as a model

The gastrointestinal tract (GIT) is exposed to various environmental pollutants including metals, that contaminate food and water which may have toxic effects on body. GIT has large amount of microbes that live in symbiosis and help the host in different ways. The resident gut microflora have a significant role to play in detoxification and elimination of the harmful metals from the body. Chromium is a naturally occurring heavy metal found commonly in environment in trivalent (Cr III) and hexavalent (Cr VI) forms. Cr (VI) compounds have been shown to be potent occupational carcinogens. The reduction of Cr (VI) to Cr (III) results in the formation of reactive intermediates that together with oxidative stress and oxidative tissue damage, and a cascade of cellular events including modulation of apoptosis regulatory gene p53 contribute to the cytotoxicity, genotoxicity and carcinogenicity of Cr(VI)-containing compounds. The data discussed here with reference to chromium show that gut microflora have a marked capacity to cope with the increased load of ingested metals and may contribute significantly in the protection against metal toxicity

Radiation Tolerant Life Forms and Methods Used to Remediate Radioactive Wastes from Soil

The expanding nuclear industry has led to increasing radioactive waste in the environment. Exposure to these wastes causes considerable irreversible damage to the organisms, some of them being even lethal. Conventional methods like incineration, wet oxidation, and acid digestion have been used for radwaste treatment to control this. Apart from them, other organic methods like bioremediation are being widely applied by scientists. Many bacteria, fungi, algae, and plants are observed to possess remediating properties. Hence, these are now used on a large scale to treat the radioactive matter as quickly and effectively as possible. Techniques like bioaccumulation, enzymatic reduction, bioprecipitation, or phytoremediation methods such as phytoextraction and phytostabilization involving such organisms with remedial abilities have successfully removed the radioactive matter to an extent from the contaminated site. Further research is needed to increase the efficiency of the techniques and help remove radionuclides in an environment-friendly manner

Dengue virus-specific suppressor T cells: current perspectives

Dengue virus was the first microorganism that was shown to induce generation of antigen-specific suppressor T (TS) cells in mice. The cascade of the three generations of TS cells (TS1, TS2, TS3) and their secretary products, the suppressor factors (SF1, SF2), was delineated. The TS pathway was proposed to be protective through inhibition of the production of enhancing antibody, which may enhance the severity of dengue disease. The currently second most favoured mechanism of severe dengue disease is the 'cytokine tsunami'. During the last decade, suppressor/regulatory T cells have been studied in greater detail using modern techniques in various diseases, including viral infections. This brief review discusses the role of dengue-specific suppressor T cells in protection and/or induction of severe dengue disease in view of our current understanding of suppressor/regulatory T cells